Cladribine has been approved for the treatment of multiple sclerosis (MS) and its administration results in a long-lasting depletion of lymphocytes.As lymphopenia is known to hamper immune responses to vaccination, we evaluated the immunogenicity of the influenza vaccine in patients undergoing cladribine treatment at different stages vs.controls.Th
No reliable evidence supports the presence of the Javan tiger: data issues related to the DNA analysis of a recent hair sample
A recent study published in Oryx proposed that the extinct Javan tiger Panthera tigris sondaica may still survive on the Island of Java, Indonesia, based on mitochondrial DNA Patio Sectional analysis of a single hair sample collected from a location where a tiger was reportedly encountered.However, upon reanalysing the genetic data presented in tha
Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress
Mehmet Zuhuri Arun,1 Buket Reel,1 Graciela B Sala-Newby,2 Mark Bond,2 Aikaterini Tsaousi,2 Perry Maskell,2 Andrew C Newby21Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey; 2Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK Background: Bisphosphonates, including zoledronate, target os
Problems of exercising the right of education in the conditions of the informational and digital reality and AI development
Background.Currently, AI technologies and systems are being purposefully in-troduced into all spheres of society and the state, their influence is becoming more and more noticeable and tangible in the implementation of human rights, including basic social rights guaranteed by the Constitution of the Russian Federation.The systems of healthcare, edu